Enrichment of GAPDH promoter DNA by Magna ChIP Protein A Magnetic Beads vs. a leading competitor’s magnetic beads in identical ChIP assays using ChIPAb+ Acetyl H3 antibody (17-615) and control rabbit IgG. GAPDH is constitutively active and its promoter is expected to be associated with acetylated Histone H3. EMD Millipore’s beads resulted in significantly greater change in PCR threshold values (ΔCT not shown) and greater fold enrichment of GAPDH promoter DNA.
Enrichment of GAPDH promoter DNA by Magna ChIP Protein A Magnetic Beads vs. a leading competitor’s magnetic beads in identical ChIP assays using ChIPAb+ Acetyl H3 antibody (17-615) and control rabbit IgG. GAPDH is constitutively active and its promoter is expected to be associated with acetylated Histone H3. EMD Millipore’s beads resulted in significantly greater change in PCR threshold values (ΔCT not shown) and greater fold enrichment of GAPDH promoter DNA.

Magna ChIP

Magna ChIP kits make it possible to complete a ChIP experiment, from cell harvest to PCR results, in a single day. Available with either protein A or protein G, Magna ChIP kits permit easy optimization for any target antibody. EZ-Magna ChIP kits also contain essential positive and negative controls to ensure high quality results.

Magna ChIP magnetic beads are optimized specifically for ChIP applications and are a rapid, reproducible, and efficient reagent for collecting immunocomplexes in ChIP assays. Unlike conventional agarose beads, Magna ChIP magnetic beads are isolated in seconds and significantly reduce the handling time and mechanical stress on target immunocomplexes.

Magna ChIP<sup>2</sup> kits enable genome-wide ChIP analysis using multiple types of microarrays. Comparative results for the Agilent human 244K promoter array (Top), Affymetrix<sup>®</sup> human promoter array (Middle) and Nimblegen™ human promoter array (Bottom) using the EMD Millipore Magna ChIP<sup>2</sup> kit.
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Magna ChIP2 kits enable genome-wide ChIP analysis using multiple types of microarrays. Comparative results for the Agilent human 244K promoter array (Top), Affymetrix® human promoter array (Middle) and Nimblegen™ human promoter array (Bottom) using the EMD Millipore Magna ChIP2 kit.

Magna ChIP2

Magna ChIP2 kits are an easy way to take your ChIP analysis genome-wide. These kits are the first and only complete solution that standardizes and simplifies ChIP-chip analysis by combining all necessary and fully optimized reagents with validated protocols and guidelines. Each Magna ChIP2 kit is designed to ensure the success, sensitivity and reproducibility using either Agilent® or user-provided DNA microarrays.

EMD Millipore’s Magna ChIP2™ chromatin immunoprecipitation DNA microarray kits are designed to make ChIP-chip analysis easily accessible and affordable with optimized reagents, user-friendly kits, and validated protocols suitable for both the novice and experienced user.

While our Magna ChIP2™ kits are specially designed for ChIP-chip, all of EMD Millipore’s standard ChIP and Magna ChIP kits are appropriate for isolating enriched DNA for genomewide ChIP-chip or ChIP-seq.