Epigenetics

Epigenetics describes heritable changes in gene expression caused by non-genetic mechanisms instead of by alterations in DNA sequence. These changes can be cell- or tissue-specific and can persist throughout a cell’s life and be passed on to multiple generations.

Nuclear Function

Epigenetic regulation enriches DNA-based information, allowing a cell to vary its response across diverse biological and environmental contexts. Although epigenetic mechanisms are primarily centered in the nucleus, these mechanisms can be induced by environmental signals such as hormones, nutrients, stress, and cellular damage, pointing to the involvement of cytoplasmic and extracellular factors in epigenetic regulation.

Epigenetic Regulation Mechanisms

$29 flat shipping charge* on shipments of any antibody purchase. Order online today or call customer service at 1-800-645-5476! Start Saving! Epigenetic regulation can occur at the transcriptional or post-transcriptional level by the following important mechanisms:

These mechanisms, in cooperation with transcription factors and other nucleic acid-binding proteins, regulate gene expression, resulting in cellular diversity using sequences that are virtually identical from cell to cell. Understanding epigenetic mechanisms of gene regulation impacts diverse areas of research, from agriculture to human health.

Epigenetics Fields of Study

Currently, researchers apply epigenetics research tools to a variety of fields of study, including:

Over the past decade, the study of epigenetics has shifted from basic mechanisms to their effect on development and disease. Throughout this time, EMD Millipore has been dedicated to developing and refining technologies for the study of epigenetic phenomena. With a comprehensive portfolio, including the former Upstate® and Chemicon® brands of reagents and antibodies, researchers can count on our dependable, high quality reagents and expert support for their studies of gene regulation.