A nucleosome consists of an octamer of histone proteins tightly associated with DNA. Accessibility to regional DNA sequences is regulated by post-translational histone modifications to these proteins.
A nucleosome consists of an octamer of histone proteins tightly associated with DNA. Accessibility to regional DNA sequences is regulated by post-translational modifications to these histone proteins.

Histone Modifications

Histone modifications regulate DNA transcription, repair, recombination, and replication, and can alter local chromatin architecture. The most commonly studied and best understood histone modifications are acetylation, phosphorylation, methylation, and ubiquitination.

Modified Histones

EMD Millipore offers over 200 validated antibodies, recombinant proteins, and kits to analyze histone modifications.

H1
H2A
H2B
H3
H4
Acetylated
Phosphorylated
Methylated
Ubiquitinated
Citrullinated
Proteins and Peptides
ChIPAb+ and Kits
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