Neural Stem Cells

Neural Stem Cells

Successful engraftment of neural stem cells (NSCs) following implantation into the brains of rodent models has demonstrated the potential of neural stem cells in the development of regenerative therapeutic strategies. Specifically, the discovery that neurons, astrocytes and oligodendrocytes arise from neural stem cells has created new opportunities for treating CNS diseases.

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NSC Antibodies
NSC Characterization Kits
NSC and Neural Progenitor Cells and Optimized Media
Browse Key NSC Markers
Nestin GFAP
CD133 Sox-2
BIII Tubulin O4

Neural Stem Cell Engraftment Analysis

Neural Stem Cells Markers
Neural Stem Cells Markers.
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The potential of neural stem cells to be used in the treatment of various neuropathies is demonstrated by their successful implantation into neonatal immunodeficient rodents. Engrafted neurons derived from transplanted human neural stem cells can be discriminated from host tissue using antibodies specific for human N-CAM or human nuclei. Proliferating cells of human origin can be detected using an antibody specific for the human nuclear protein Ki-67. This protein is expressed by human cells in all phases of the active cycle and is absent in the resting phase.

The detection of implanted, pre-differentiated cells can be accomplished by labeling of proliferating and differentiating cells with BrdU prior to implantation. Resulting neurons and glia can be detected using an anti-BrdU antibody.

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Browse All Antibodies and Kits for Engraftment Analysis
Browse All Antibodies for Mitosis Markers
Browse All Antibodies for Neuroregenerative Medicine
Browse Key Mitosis Markers
pHH3 Ser10 Anti-Mitotic Cell Antigen
ki-67 BrdU
PCNA MPM-2