Final Aseptic Fill

Recommended Filter	Filter Characteristics
Durapore 0.22 µm Filters Cartridge Filters Optiseal Cartridge Filters Opticap Capsule Filters Optiseal Capsule Fitlers	Low protein-binding sterilizing-grade PVDF membrane Bacterial retentive membrane has been the proven industry standard for decades Very low extractables preserve product purity and yield High flow rate at low pressure drop for reliable economic processing 100% integrity testing and thousands of applications assures proven performance Validated for multiple SIP and hot water sanitization cycles Integrity testable on-site Available in Millipak stacked disc format which allows minimal hold-up volume Although 0.22 µm membrane is ideal for this application, Durapore filters are available in several pore sizes and in single-layer or multi-layer configurations to accommodate the needs of each user. Choice should be based on small-scale testing.

Recommended Filter

Filter Characteristics

Low protein-binding sterilizing-grade PVDF membrane
Bacterial retentive membrane has been the proven industry standard for decades
Very low extractables preserve product purity and yield
High flow rate at low pressure drop for reliable economic processing
100% integrity testing and thousands of applications assures proven performance
Validated for multiple SIP and hot water sanitization cycles
Integrity testable on-site
Available in Millipak stacked disc format which allows minimal hold-up volume
Although 0.22 µm membrane is ideal for this application, Durapore filters are available in several pore sizes and in single-layer or multi-layer configurations to accommodate the needs of each user. Choice should be based on small-scale testing.

ALTERNATIVE: For high flow applications or if a PES membrane is requested, sterilizing-grade Millipore Express PES Filters are available.

Recommended Filter	Filter Characteristics
Milligard Filters (Grade SS, 0.5 µm + 0.2 µm) Cartridge Filters Opticap Capsule Filters Optiscale Capsule Filters	Available in double-layer pleated configurations for increased particle and colloid loading capacity Mixed esters of cellulose filter material with low protein-binding characteristics Low extractables and non-fiber releasing High flow rate at low pressure drop Validated for multiple SIP cycles Decades of proven performance protecting membrane filters 100% integrity tested Although grade SS, 0.5 µm + 0.2 µm is commonly used to protect downstream 0.22 µm sterilizing-grade membrane filters, Milligard filters are available in several pore sizes and in single-layer or multi-layer configurations. Choice should be based on small-scale testing.

Recommended Filter

Filter Characteristics

Available in double-layer pleated configurations for increased particle and colloid loading capacity
Mixed esters of cellulose filter material with low protein-binding characteristics
Low extractables and non-fiber releasing
High flow rate at low pressure drop
Validated for multiple SIP cycles
Decades of proven performance protecting membrane filters
100% integrity tested
Although grade SS, 0.5 µm + 0.2 µm is commonly used to protect downstream 0.22 µm sterilizing-grade membrane filters, Milligard filters are available in several pore sizes and in single-layer or multi-layer configurations. Choice should be based on small-scale testing.

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