Understanding the Options

Buffer Preparation

Sterile Filtration

• Utilize a sterilizing-grade membrane to remove contaminants and ensure sterility
• Must work with a variety of process fluids across a range of pH levels
• Preserve product purity
• Able to withstand demanding steam-in-place requirements

Recommended Filter	Filter Characteristics
Single-layer Millipore Express SHF 0.2 mm Filters Cartridges Opticap Capsules Optiscale Capsules	Sterilizing-grade PES membrane providing broad chemical compatibility across a wide pH range (1–14) Robust construction validated for multiple SIP cycles 100% integrity tested to ensure quality Asymmetric pore structure delivers extremely high flow rates at low pressure drop Can be integrity tested on-site
Double-layer Millipore Express SHC 0.5 mm + 0.2 mm Filters Cartridges Opticap Capsules Optiscale Capsules	Sterilizing-grade PES membrane with an additional PES prefilter layer all in one pleated device Double-layer construction provides excellent capacity even in high salt conditions PES membrane provides broad chemical compatibility across a wide pH range (1–14) Robust construction validated for multiple SIP cycles 100% integrity tested to ensure quality Asymmetric PES pore structure delivers extremely high flow rates at low pressure drop Can be integrity tested on-site