Buffer Preparation

Utilize a sterilizing-grade membrane to remove contaminants and ensure sterility
Must work with a variety of process fluids across a range of pH levels
Preserve product purity
Able to withstand demanding steam-in-place requirements

Recommended Filter	Filter Characteristics
Single-layer Millipore Express SHF 0.2 mm Filters Cartridges Opticap Capsules Optiscale Capsules	Sterilizing-grade PES membrane providing broad chemical compatibility across a wide pH range (1–14) Robust construction validated for multiple SIP cycles 100% integrity tested to ensure quality Asymmetric pore structure delivers extremely high flow rates at low pressure drop Can be integrity tested on-site
Double-layer Millipore Express SHC 0.5 mm + 0.2 mm Filters Cartridges Opticap Capsules Optiscale Capsules	Sterilizing-grade PES membrane with an additional PES prefilter layer all in one pleated device Double-layer construction provides excellent capacity even in high salt conditions PES membrane provides broad chemical compatibility across a wide pH range (1–14) Robust construction validated for multiple SIP cycles 100% integrity tested to ensure quality Asymmetric PES pore structure delivers extremely high flow rates at low pressure drop Can be integrity tested on-site

ALTERNATIVES:If a PVDF membrane is needed, Millipore’s Durapore Family of Filters have been a proven performer for decades.

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