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Understanding the Options:

Ophthalmic Solutions





Prefiltration

Essential Process Requirements
  • Reduce particles and bioburden
  • Extend the life of final filters
  • Must be robust for high volume processes
  • Run efficiently for optimal process economics

Recommended FilterFilter Characteristics

Double-layer Polysep II Filters
(Grade W6, 1 µm + 0.5 µm)
Cartridge Filters
Opticap Capsule Filters
Optiscale Capsule Filters
  • Borosilicate glass top layer enhances particle and loading capacity in high solute applications
  • Mixed esters of cellulose membrane bottom layer ensures high retention and filtrate quality
  • Robust construction validated to withstand multiple SIP or hot water sanitization cycles
  • Non-fiber releasing structure preserves product purity
  • 100% integrity tested to ensure quality
  • Available in a variety of pore sizes to accommodate the needs of each user. Grade W6 is commonly used in this application. Choice should be made based on small-scale testing.

Sterile Filtration

Essential Process Requirements
  • Sterilizing-grade filter to remove microorganisms
  • Operate consistently at high flow rates
  • Must be robust for high volume processes
  • Run efficiently to ensure process economics

Recommended FilterFilter Characteristics

Charged Durapore 0.22 µm Filters
Cartridge Filters
Optiseal Cartridges
  • Sterilizing-grade PVDF membrane
  • Ideal solution when preservative binding is a concern
  • High flow rates and throughput, low extractables and protein binding
  • 100% Integrity testing to ensure performance

Millipore Express SHF 0.2 µm Filters
Cartridge Filters
Opticap Capsule Filters
Optiscale Capsules
  • Sterilizing-grade PES membrane providing broad chemical compatibility across a wide pH range (1–14)
  • Asymmetric pore structure delivers extremely high flow rates at low preservative binding
  • 100% integrity tested to ensure quality