Cell Harvest Clarification
The clarification of biological products such as recombinant proteins, monoclonal antibodies or vaccines requires choosing technology that works for your process; ensuring product consistency and reproducibility and high yields. The clarification process entails the separation of large molecules with high molecular weight such as proteins from cells, cell debris, colloids, and particles.
The consideration of filter types for cell culture clarification should be based on the fluid and the process step immediately preceding and following the clarification step. Because a prefilter may be required as insurance against fouling downstream membranes or columns look for filters that combine enhanced capacity and protections, such as Millistak+ HC depth filters.
Millipore offers a wide array of additional filtration solutions that easily scale from small scale devices to full-scale systems that optimize quality, cost, and capacity delivering consistent results you can trust.
Millistak+ HC Filters—don’t wait a second step longer
Two steps on one device. Millistak+HC filters compress the clarification process, saving time, space and resources.
Process Compression, Half the Hardware
Now, even more flexibility with the new Pod filter platform: Modular. Self-contained. Disposable |
The Millipore Disposable NFF Pod Filter System delivers unprecedented flexibility for clarification and prefiltration applications.
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Millipore ProStak microfiltration is the prevailing TFF clarification technology used by monoclonal producers around the globe
| TFF separates particles using size exclusion to efficiently remove up to 99.5% of all whole cells, cell debris and other particles. The MF membrane pore size can range from 0.1 to 0.65 microns. The selection of a tighter membrane 0.1 to 0.2 microns can facilitate the removal of lipids and other colloids. To learn more take a look at our Pellicon MF and Prostak devices and systems. | Prostak system |
