Intracellular Cancer Biomarkers

Cell signaling pathway proteins and their post-translational modifications have shown potential to be used as cancer biomarkers. Errors in cell signaling pathways, caused by mutations that may result in the constitutive expression or total inhibition of protein transcription, are common across many tumor types, including lung cancer, prostate cancer, and breast cancer.

Millipore’s MILLIPLEX MAP immunoassays and multiplex assay kits enable you to quantify biomarkers from key cell signaling pathways that regulate tumorigenesis or metastasis, including apoptosis, immune signaling, Akt mTOR pathway, and the MAPK pathway.

Quantitative Cell Signaling Analysis With MILLIPLEX MAP EpiQuant Technology
Also using the Luminex xMAP platform, MILLIPLEX MAP EpiQuant technology differs from traditional multiplex cell signaling assays because it can measure site-specific phosphorylation of cancer biomarkers, enabling quantitative cell signaling analysis across pathways and between multiple steps of a single pathway.

MILLIPLEX MAP Multi-species Pyruvate Dehydrogenase (PDH) Complex Magnetic Bead Panel
Catalogue Number: PDHMAG-13KK (magnetic)
  • PDH (total)
  • PDH (pS232)
  • PDH (pS293)
  • PDH (pS300)
Human Multi-Pathway 8 Plex
Catalogue Number: 48-680 (nonmagnetic)
  • CREB (Ser133)
  • Erk/MAPK 1/2 (Thr185/Tyr187)
  • IκBα (Ser32)
  • JNK/SAPK1 (Thr183/Tyr185)
  • STAT3 (Ser727)
  • STAT5A/B (Tyr694/699)
  • p38/SAPK2A/B (Thr180/Tyr182)
  • p70 S6 Kinase (Thr412)
Human T Cell Receptor – 7 Plex
Catalogue Number: 48-690 (nonmagnetic)
  • CD3ε (pan Tyr)
  • CREB (Ser133)
  • Erk/MAPK 1/2 (Thr185/Tyr187)
  • LAT (pan Tyr)
  • Lck (pan Tyr)
  • Syk (pan Tyr)
  • ZAP-70 (pan Tyr)
Human MAP/SAPK 10 Plex
Catalogue Number: 48-660 (nonmagnetic)
  • ATF2 (Thr69/71)
  • c-Jun (Ser73)
  • Erk/MAPK 1/2 (Thr185/Tyr187)
  • HSP27 (Ser78)
  • JNK/SAPK1 (Thr183/Tyr185)
  • MEK1 (Ser222)
  • MSK1 (Ser212)
  • p38/SAPK2A/B (Thr180/Tyr182)
  • p53 (Ser15)
  • STAT1 (Tyr701)
Human Src Family Kinase 8 Plex
Catalogue Number: 48- 650 (nonmagnetic)
  • Blk
  • Fgr
  • Fyn
  • Hck
  • Lck
  • Lyn
  • Src
  • Yes
Human Akt/mTOR 11 Plex
Catalogue Number: 48-611 (nonmagnetic)
  • Akt (Ser473)
  • GSK3α (Ser21)
  • GSK3β (Ser9)
  • IGF-1R
  • IR (Tyr1162/Tyr1163)
  • IRS1 (Ser312)
  • mTOR (Ser2448)
  • p70S6K (Thr412)
  • PTEN (Ser380)
  • RPS6 (Ser235/Ser236)
  • TSC2 (Ser939)
Human Apoptosis 3 Plex
Catalogue Number: 48-670 (nonmagnetic)
  • Caspase 3 (Active)
  • GAPDH (Total)
  • PARP (Cleaved)