New Product Spotlight
Detecting qualified kidney toxicity biomarkers, in contrast to traditional BUN and serum creatinine tests, can enable early detection and localization of kidney damage, which are crucial for accurate assessment of toxicity
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Featured New Panels:
MILLIPLEX® MAP Canine Kidney Toxicity Magnetic Bead Panel 1
(Cat. No. CKTX1MAG-97K)
As drug development moves forward, it is important to assess kidney toxicity biomarkers in other pre-clinical species, specifically in canine. We are the first provider to offer you a kit to assess three very important kidney toxicity biomarkers in Canine samples: Clusterin, Cystatin C, and KIM-1.
MILLIPLEX® MAP Rat Kidney Toxicity Magnetic Bead Panels 1 and 2
(Cat. Nos. RKTX1MAG-37K and RKTX2MAG-37K)
The Relevance of Toxicity Studies
Toxicity affects all facets of biological research and drug development. Measuring biomarkers related to key toxicity pathways including apoptosis, hypoxia, or oxidative stress, can be effective in interpreting cellular or organismal studies, understanding pathophysiology, stratifying patient populations, and eliminating toxic compounds early in drug development pipelines.Millipore’s Toxicity Assays
Bead-based multiplex immunoassays enable precise, multiparametric analysis of the concurrent processes that underlie toxicity. Our MILLIPLEX MAP multiplex toxicity biomarker panels and ELISAs make us the leading partner for toxicity testing research.
Millipore provides toxicology leadership at every stage of drug discovery and development. While cost and speed are critical, biological relevance is just as vital; our customers work with us to evolve the science of toxicity testing. Together, we analyze how cytotoxic substances can cause oxidative stress, necrosis, apoptosis, or growth arrest in one or more systems in the body. The major classes of toxicity are:
- Neurotoxicity: brain, spinal cord, or peripheral nervous system toxicity
- Cardiotoxicity: affecting the heart or vasculature
- Hepatotoxicity: liver toxicity
- Nephrotoxicity: kidney toxicity
Cryopreserved HepaRG™ cells.
Improved reproducibility and function for better ADME/Tox data.
Now the supplier for Biopredic’s original, widely cited HepaRG™ cells, manufactured by them to the highest quality standards.
Recommended Working Volumes
