Ordering Information
Product Images
WB: Raji cell lysate probed with anti-BTK at 1:1000 dilution.
Anti-BTK
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | Chromatin Immunoprecipitation (ChIP), IP, WB | Mouse | Ascites | Monoclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: Q06187 # Plays a crucial role in B-cell ontogeny. Transiently phosphorylates GTF2I on tyrosine residues in response to B-cell receptor cross-linking. Required for the formation of functional ARID3A DNA-binding complexes.
COFACTOR: Binds 1 zinc ion per subunit.
SIZE: 659 amino acids; 76281 Da
SUBUNIT: Binds GTF2I through the PH domain. Interacts with SH3BP5 via the SH3 domain. Interacts with IBTK via its PH domain. Interacts with GTF2I ... see more »
COFACTOR: Binds 1 zinc ion per subunit.
SIZE: 659 amino acids; 76281 Da
SUBUNIT: Binds GTF2I through the PH domain. Interacts with SH3BP5 via the SH3 domain. Interacts with IBTK via its PH domain. Interacts with GTF2I ... see more »
Entrez Gene Number:
Entrez Gene Summary
Defects in the Bruton tyrosine kinase (BTK) gene cause Agammaglobulinemia. Agammaglobulinemia is an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement.
Description:
Anti-BTK
Specificity:
BTK
Key Applications:
- Chromatin Immunoprecipitation (ChIP)
- Immunoprecipitation
- Western Blotting
Application Notes:
Not recommended for IPK or ICC.
Species Reactivity:
Human
Isotype:
IgG1
Immunogen:
Partial fusion protein corresponding to residues 1-175 of human BTK; clone 10D11
Molecular Weight:
77kDa
Presentation:
mouse ascites containing 0.02% sodium azide
Storage Conditions:
2 years at -20°C
Gene Symbol:
- BTK
- MGC126261
- ATK
- XLA
- AT
- PSCTK1
- IMD1
- OTTHUMP00000063593
- BPK
- AGMX1
- MGC126262
Quality Assurance:
routinely evaluated by immunoblot on RIPA lysates from Raji cells
Antibody Category:
Signaling
Antibody Sub-Category:
Immunological Signaling
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Upstate (Millipore)
Format:
Ascites
Host:
Mouse
Antibody Type:
Monoclonal Antibody
Purification Method:
ascites