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WB: Non-stimulated (lane 1) and PMA-stimulated (lane 2) human red blood cell lysate, was probed with anti-phospho-Adducin, clone pADD (S724) (0.5μg/ml...
Anti-phospho-Adducin (Ser724), clone pADD
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | IP, WB, IC | Mouse | Purified | Monoclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: P35611 # Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
SIZE: 737 amino acids; 80955 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit. Binds ROCK1.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
TISSUE SPECIFICITY: Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.
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SIZE: 737 amino acids; 80955 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit. Binds ROCK1.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
TISSUE SPECIFICITY: Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.
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Entrez Gene Number:
Entrez Gene Summary
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissu
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Description:
Anti-phospho-Adducin (Ser724), clone pADD
Trade Name:
Upstate (Millipore)
Key Applications:
- Immunoprecipitation
- Western Blotting
- Immunocytochemistry
Species Reactivity:
- Human
- Mouse
- Rat
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular Weight:
80-120kDa
Quality Assurance:
routinely evaluated by immunoblot on lysates from human red blood cells stimulated with PMA
Immunogen:
peptide (FRTP[pS]FLKK) corresponding to amino acids 720-728 of rat phospho-α-Adducin (Ser724)
Format:
Purified
Presentation:
0.7M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol.
Storage Conditions:
2 years at -20°C
Host:
Mouse
Isotype:
IgG
Modifications:
Phosphorylation
Gene Symbol:
- ADD1
- ADDA
- Alpha-adducin
- MGC44427
- MGC3339
Antibody Category:
Cell Structure
Antibody Sub-Category:
Cytoskeleton
Antibody Type:
Monoclonal Antibody
Specificity:
phospho-Adducin isoforms
Purification Method:
Protein G Chromatography