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WB: 200 nanograms of recombinant Bad (14-357) phosphorylated with PKA (14-111) (Lane 2) and unphosphorylated (Lane 1) was probed with Anti-phospho-Ba...
Anti-phospho-Bad (Ser155), clone JBW101
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | WB | Mouse | Purified | Monoclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: Q92934 # Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
SIZE: 168 amino acids; 18392 Da
SUBUNIT: Forms heterodimers with the anti-apoptotic pr ... see more »
SIZE: 168 amino acids; 18392 Da
SUBUNIT: Forms heterodimers with the anti-apoptotic pr ... see more »
Entrez Gene Number:
Entrez Gene Summary
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein
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Description:
Anti-phospho-Bad (Ser155), clone JBW101
Trade Name:
Upstate (Millipore)
Key Applications:
Western Blotting
Species Reactivity:
- Human
- Mouse
- Rat
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular Weight:
30kDa
Quality Assurance:
routinely evaluated by immunoblot on recombinant soluble murine Bad (Catalog #14-357) phosphorylated at Ser155 by PKA (Catalog #14-111)
Immunogen:
synthetic peptide (C-YGRELRRM[pS]DEFEG) corresponding to amino acids 147-160 of mouse Bad
Format:
Purified
Presentation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide, 5mg/ml BSA before the addition of glycerol to 30%
Storage Conditions:
2 years at -20°C
Host:
Mouse
Isotype:
IgG2b
Modifications:
Phosphorylation
Gene Symbol:
- BAD
- BBC2
- BBC6
- BCL2L8
Antibody Category:
Apoptosis & Cancer
Antibody Sub-Category:
BCL2 & Inhibition
Antibody Type:
Monoclonal Antibody
Specificity:
phosphorylated Bad
Purification Method:
Protein G chromatography