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WB: MBP (Lane 1) and MBP phosphorylated in vitro with MAP Kinase 2/Erk2, active (14-173) were probed with anti-phospho-MBP.
Anti-phospho-MBP, clone BK403
| Espèces réactives | Principales applications | Hôte | Forme | Type d'anticorps |
|---|---|---|---|---|
| Vrt | WB | Mouse | Purified | Monoclonal Antibody |
Code UniProt:
UniProt Summary
FUNCTION: SwissProt: P02686 # The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination
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Code GenBank:
Entrez Gene Summary
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP
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Description:
Anti-phospho-MBP, clone BK403
Clone:
BK403
Specificity:
Recognizes in-vitro phosphorylated myelin basic protein.
Key Applications:
Western Blotting
Species Reactivity:
Vertebrates
Isotype:
IgG1κ
Immunogen:
peptide containing the seqeunce PRpTPP in which pT corresponds to phosphorylated threonine residue 98 of phosphorylated human MBP (myelin basic protein)
Modifications:
Phosphorylation
Molecular Weight:
~18-23 kDa
Control:
Brain tissue
Presentation:
Protein A Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide as a preservative.
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Gene Symbol:
- MBP
- MGC99675
Quality Assurance:
routinely evaluated by immunoblot on phosphorylated MBP after incubation with MAP Kinase 2/Erk2, active (Catalog # 14-173). Note: Some preparations of MBP contain basal levels of phosphorylated MBP
Antibody Category:
Signaling
Antibody Sub-Category:
MAP Kinases
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Upstate (Millipore)
Format Code:
Pur
Concentration:
0.86 mg/mL
Antibody Type:
Monoclonal Antibody
Format:
Purified
Host:
Mouse
Purification Method:
Protein G Purified