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Ordering Information

  • : 05-779
  • : 100 µL

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WB: A 1:1,000-1:5,000 dilution of this lot detected Meis in nuclear extract from K562 cells.

Anti-Meis 1/2/3 Antibody, clone 9.2.7

Species Reactivity Key Applications Host Format Antibody Type
H, M IP, WB, IHC Mouse Ascites Monoclonal Antibody
Description:
Anti-Meis 1/2/3 Antibody, clone 9.2.7
Promotional Text:
Trade Name:
Upstate (Millipore)
Specificity:
Meis1, Meis2, Meis3 and splice variants
Molecular Weight:
Mr ~45-66kDa
Immunogen:
MBP-conjugated fusion protein corresponding to amino acids 60-390 of mouse Meis1
Isotype:
Background Information:
Hox, Pbx, and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains. Meis1, 2, and 3 are members of the TALE (three amino acid loop extension) family of homeodomain containing proteins. Meis1 binds to Hox and Pbx proteins to form complexes with distinct DNA-binding specificities. Like Hox and Pbx proteins, the overexpression of Meis1 in BHX-2 myeloid leukemias implies a role for this protein in oncogenesis. Two Meis related proteins, Meis2 and Meis3 (also designated Mrg1 and Mrg2, respectively), possess largely similar sequence identity with Meis1 and express in normal tissues as well as myeloid leukemias. In the pancreas, Meis2 preferentially associates with Pbx1, and together they associate with the pancreas specific homeodomain factor, Pdx1, to repress Pdx1-induced transcriptional activation.
Species Reactivity:
  • Human
  • Mouse
Control:
K562 nuclear extract
Quality Assurance:
routinely evaluated by immunoblot on nuclear extract from K562 cells
Purification Method:
Ascites
Presentation:
mouse ascites IgG1 containing 0.05% sodium azide before the addition of glycerol to 30%
Storage Conditions:
2 years at -20°C
UniProt Number:
Entrez Gene Number:
Gene Symbol:
  • MEIS2
  • MGC2820
  • MRG1
  • HsT18361
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
  • Immunoprecipitation
  • Western Blotting
  • Immunohistochemistry
Entrez Gene Summary:
This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.
UniProt Summary:
SIZE: 477 amino acids; 51790 Da
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Expressed in various tissues. In hematopoietic tissues, the lymphoid organs express high levels of MEIS2. Also expressed in some regions of the brain, such as the putamen.
SIMILARITY: SwissProt: O14770 ## Belongs to the TALE/MEIS homeobox family. & Contains 1 homeobox DNA-binding domain.
Brand Family:
Upstate
Product Name:
Anti-Meis 1/2/3 Antibody, clone 9.2.7
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µL
Format:
Ascites
Host:
Mouse
Applications:
Detect Meis 1/2/3 with Anti-Meis 1/2/3 Antibody, clone 9.2.7 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB & IHC.

Product Resources

View Gene Related Products for this Target

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