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WB: Jurkat cell lysate probed with anti-Bcl-3 at 1μg/ml
Anti-Bcl-3
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | IP, WB, IC | Rabbit | Purified | Polyclonal Antibody |
Description:
Anti-Bcl-3
Trade Name:
Upstate (Millipore)
Product Overview:
This antibody works well on Bcl3 transfected cell lysates; it does not effectively blot endogenous levels of Bcl3 from RIPA cell lysates
Specificity:
Bcl3
Molecular Weight:
47kDa
Immunogen:
Fusion protein containing amino acid residues 290-421 of human Bcl-3
Isotype:
IgG
Species Reactivity:
Human
Quality Assurance:
routinely evaluated by immunoblot on a Bcl3 transfected Cos-1 cell lysate
Purification Method:
Protein A chromatography
Presentation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide
Storage Conditions:
2 years at -20°C
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- BCL3
- D19S37
- BCL4
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.
Key Applications:
- Immunoprecipitation
- Western Blotting
- Immunocytochemistry
UniProt Summary:
FUNCTION: SwissProt: P20749 # Could be a transcriptional activating factor. Functions as a form of I-kappa-B specific for NF-kappa-B p50 subunit inhibiting its translocation to the nucleus.
SIZE: 446 amino acids; 46800 Da
SUBUNIT: Interacts with N4BP2 and COPS5.
SUBCELLULAR LOCATION: Nucleus.
PTM: Activated by phosphorylation.
DISEASE:SwissProt: P20749 # A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.
SIMILARITY: SwissProt: P20749 ## Contains 7 ANK repeats.
SIZE: 446 amino acids; 46800 Da
SUBUNIT: Interacts with N4BP2 and COPS5.
SUBCELLULAR LOCATION: Nucleus.
PTM: Activated by phosphorylation.
DISEASE:SwissProt: P20749 # A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.
SIMILARITY: SwissProt: P20749 ## Contains 7 ANK repeats.
Qty/Pk:
200 µg
Brand Family:
Upstate
Format:
Purified
Host:
Rabbit
Product Name:
Anti-Bcl-3
Antibody Type:
Polyclonal Antibody