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WB: C4 cell membrane extract probed with anti-IGF-I Receptor α subunit at 4μg/ml
Anti-IGF-IRα subunit
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M | IC, IP, WB | Chicken | Purified | Polyclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: P08069 # This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade.
SIZE: 1367 amino acids; 154793 Da
SUBUNIT: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the bet ... see more »
SIZE: 1367 amino acids; 154793 Da
SUBUNIT: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the bet ... see more »
Entrez Gene Number:
Entrez Gene Summary
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
Description:
Anti-IGF-IRα subunit
Specificity:
Recognizes IGF-I receptor alpha-subunit.
Key Applications:
- Immunocytochemistry
- Immunoprecipitation
- Western Blotting
Species Reactivity:
- Human
- Mouse
Isotype:
IgY
Immunogen:
19 residue synthetic peptide [C-KYADGTIDIEEVTENPKT] corresponding to amino acid residues (642-659) of human IGF-I receptor alpha-subunit
Molecular Weight:
130 kDa
Control:
C4 cell lysate, HepG2 cells
Presentation:
Protein A Purified immunoglobulin in 0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol.
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Gene Symbol:
- IGF1R
- MGC142170
- IGFIR
- MGC18216
- JTK13
- MGC142172
- CD221
Quality Assurance:
routinely evaluated by immunoblot on membranes prepared from 3T3 cells expressing the human IGF-I receptor
Antibody Category:
Signaling
Antibody Sub-Category:
Insulin/Energy Signaling
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Upstate (Millipore)
Format Code:
Pur
Concentration:
1 mg/mL
Antibody Type:
Polyclonal Antibody
Format:
Purified
Host:
Chicken
Purification Method:
Ammonium sulfate precipitation