Content Loading...
Content Loading...
Product Images
WB: Rat kidney microsomal preparation was probed with anti-Cathepsin B (4μg/ml); proCathepsin B (~40kDa) and mature Cathepsin B (~25 & 30kDa).
Anti-Cathepsin B
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M, R | IH, WB | Rabbit | Purified | Polyclonal Antibody |
Description:
Anti-Cathepsin B
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes procathepsin B and mature cathepsin B.
Molecular Weight:
procathepsin B (40 kDa) and mature cathepsin B (25 kDa, 26 kDa and 30 kDa)
Immunogen:
Recombinant rat procathepsin B 1
Isotype:
IgG
Species Reactivity:
- Mouse
- Rat
Control:
A431 Cell Lysate
Quality Assurance:
routinely evaluated by immunoblot on rat kidney microsomal preparation (Catalog #12-146)
Purification Method:
Protein A purfied
Presentation:
Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- CTSB
- CPSB
- APPS
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.
Key Applications:
- Immunohistochemistry
- Western Blotting
UniProt Summary:
FUNCTION: SwissProt: P07858 # Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
SIZE: 339 amino acids; 37822 Da
SUBUNIT: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.
SUBCELLULAR LOCATION: Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SIMILARITY: SwissProt: P07858 ## Belongs to the peptidase C1 family.
SIZE: 339 amino acids; 37822 Da
SUBUNIT: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.
SUBCELLULAR LOCATION: Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SIMILARITY: SwissProt: P07858 ## Belongs to the peptidase C1 family.
Qty/Pk:
400 μg
Brand Family:
Upstate
Format:
Purified
Host:
Rabbit
Packaging:
2 vials of 200 μg
Product Name:
Anti-Cathepsin B
Antibody Type:
Polyclonal Antibody