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Ordering Information

  • : 06-676
  • : 200 µg

Product Images

WB: Rat brain microsome extract probed with anti-mGluR2/3 at 0.5μg/ml

Anti-mGluR2/3 Antibody

Species Reactivity Key Applications Host Format Antibody Type
M, R IHC, IP, WB Rabbit Purified Polyclonal Antibody
Description:
Anti-mGluR2/3 Antibody
Promotional Text:
Trade Name:
Upstate (Millipore)
Specificity:
mGluR2 and mGluR3
Molecular Weight:
100-110kDa
Immunogen:
peptide (KQFVPTVCNGREVVDSTTSSL) corresponding to amino acids 853-872 of human metabotropic glutamate receptor 2
Isotype:
Species Reactivity:
  • Mouse
  • Rat
Quality Assurance:
routinely evaluated by immunoblot on rat brain microsomal preparation
Purification Method:
Protein A chromatography
Presentation:
0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol
Storage Conditions:
2 years at -20°C
UniProt Number:
Entrez Gene Number:
Gene Symbol:
  • GRM2
  • GPRC1B
  • MGLUR2
  • GLUR2
  • mGlu2
  • mGluR2
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
  • Immunohistochemistry
  • Immunoprecipitation
  • Western Blotting
Entrez Gene Summary:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
UniProt Summary:
FUNCTION: SwissProt: Q14416 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
SIZE: 872 amino acids; 95568 Da
SUBUNIT: Interacts with GRASP (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed in different regions of the adult brain as well as in fetal brain.
SIMILARITY: SwissProt: Q14416 ## Belongs to the G-protein coupled receptor 3 family.
Brand Family:
Upstate
Product Name:
Anti-mGluR2/3 Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
200 µg
Format:
Purified
Host:
Rabbit
Applications:
Anti-mGluR2/3 Antibody is an antibody against mGluR2/3 for use in IH, IP & WB.

Product Resources

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