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WB: 3T3/NIH cell lysate was probed with anti-phospho-Adducin (Ser662) (2μg/ml).
Anti-phospho-Adducin (Ser662)
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| Ca, H, M, R | WB | Rabbit | Affinity Purified | Polyclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: Q9UEY8 # Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
SIZE: 706 amino acids; 79155 Da
SUBUNIT: Heterodimer of an alpha and a gamma subunit.
TISSUE SPECIFICITY: Heart only expresses isoform 1.
DOMAIN:SwissProt: Q9UEY8 Comprised of three regions: a N-terminal protease- resistant globular head region, a short connecting subdomain, and a protease-sensit ... see more »
SIZE: 706 amino acids; 79155 Da
SUBUNIT: Heterodimer of an alpha and a gamma subunit.
TISSUE SPECIFICITY: Heart only expresses isoform 1.
DOMAIN:SwissProt: Q9UEY8 Comprised of three regions: a N-terminal protease- resistant globular head region, a short connecting subdomain, and a protease-sensit ... see more »
Entrez Gene Number:
Entrez Gene Summary
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally pur
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Description:
Anti-phospho-Adducin (Ser662)
Specificity:
phosphorylated serine 662 of γ-Adducin, phosphorylated serine 724 of α-Adducin, phosphorylated serine 713 of β-Adducin
Key Applications:
Western Blotting
Species Reactivity:
- Canine
- Human
- Mouse
- Rat
Isotype:
IgG
Immunogen:
peptide (C-KKFRTPpSFLKKNK) corresponding to amino acids 656-668 of human gamma-Adducin
Modifications:
Phosphorylation
Molecular Weight:
80kDa, 120kDa, 110kDa
Presentation:
0.014 M phosphate buffer, pH 7.6, 0.175 M NaCl, 0.07% sodium azide, and 30% glycerol. Liquid at -20°C.
Storage Conditions:
1 year at -20°C
Gene Symbol:
- ADD3
- adducin-like
- ADDL
- Gamma-adducin
Quality Assurance:
routinely evaluated by immunoblot on RIPA lysates from 3T3/NIH cells or on canine MDCK cells
Antibody Category:
Cell Structure
Antibody Sub-Category:
Cytoskeleton
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Upstate (Millipore)
Format:
Affinity Purified
Host:
Rabbit
Antibody Type:
Polyclonal Antibody
Purification Method:
immunoaffinity purified