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Anti-phospho-STAT5A/B (Ser726/Ser731)
| 交差性 | 主要アプリケーション | 免疫動物 | フォーマット | 抗体タイプ |
|---|---|---|---|---|
| H, M, R | WB | Rabbit | Serum | Polyclonal Antibody |
Description:
Anti-phospho-STAT5A/B (Ser726/Ser731)
Trade Name:
Upstate (Millipore)
Specificity:
phosphorylated STAT5A (S726) and STAT5B (S731), does not recognize STAT5B containing a S731A mutation
Molecular Weight:
94kDa
Immunogen:
peptide (DQAP[pS]PAVC) corresponding to amino acids 722-730 of human STAT5A or 727-735 of human STAT5B
Modifications:
Phosphorylation
Isotype:
IgG
Species Reactivity:
- Human
- Mouse
- Rat
Quality Assurance:
routinely evaluated by immunoprecipitating STAT5A from RIPA lysates of Nb2-Sp cells that had been treated with prolactin; subsequent immunoblotting was performed using Anti-STAT5A (Catalog #06-968)
Purification Method:
Antiserum
Presentation:
rabbit antiserum in 30% glycerol and 0.05% sodium azide
Storage Conditions:
2 years at -20°C
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- STAT5A
- MGF
- STAT5
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: P42229 # Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
SIZE: 794 amino acids; 90647 Da
SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
PTM: Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL- 15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA- binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).
SIMILARITY: SwissProt: P42229 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
SIZE: 794 amino acids; 90647 Da
SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
PTM: Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL- 15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA- binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).
SIMILARITY: SwissProt: P42229 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
Qty/Pk:
200 µL
Brand Family:
Upstate
Format:
Serum
Host:
Rabbit
Product Name:
Anti-phospho-STAT5A/B (Ser726/Ser731)
Antibody Type:
Polyclonal Antibody