Ordering Information
- : 07-103
- : 100 μg
- : 1.0 mg/mL
Product Images
Western Blot Analysis:
Representative lot data.
HEK293 cell lysate was resolved by electrophoresis, transferred to PVDF membranes and probed...
Western Blot (Snap ID) Analysis:
Representative lot data.
HEK293 cell lysate was resolved by electrophoresis, transferred to PVDF membranes ...
Anti-IGF2 mRNA-binding protein 2
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, Chp, B | WB | Rabbit | Affinity Purified | Polyclonal Antibody |
Description:
Anti-IGF2 mRNA-binding protein 2 Antibody | 07-103
Promotional Text:
Specificity:
This antibody recognizes IGF2 mRNA-binding protein 2.
Molecular Weight:
62 kDa. Predicted to cross-react with all the Isoforms of IGF2 mRNA-binding protein 2
Epitope:
Internal Domain
Immunogen:
KLH-conjugated linear peptide corresponding to human IGF2 mRNA-binding protein 2 at and around the internal domain.
Background Information:
The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
Species Reactivity:
- Human
- Chimpanzee
- Bovine
Species Reactivity Note:
Reacts with human. Predicted to react with chimpanzee, Rhesus monkey, and cow based on 100% sequence homology.
Application Notes:
Western Blot (SNAP ID) Analysis: 4 µg/mL from a previous lot detected IGF2 mRNA-binding protein 2 on 10 µg of Hek293 lysate.
Control:
Hek293 cell lysate
Quality Assurance:
Evaluated by Western Blot in Hek293 cell lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected IGF2 mRNA-binding protein 2 on 10 µg of Hek293 lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected IGF2 mRNA-binding protein 2 on 10 µg of Hek293 lysate.
Purification Method:
Affinity Purfied
Presentation:
Purified rabbit serum in PBS with 0.09% azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- IGF2BP2
- IMP-2
- IMP2
- VICKZ2
- p62
Alternate Names:
- Hepatocellular carcinoma autoantigen p62
- IGF-II mRNA-binding protein 2
- IGF2 mRNA-binding protein 2
- VICKZ family member 2
- insulin-like growth factor 2 mRNA binding protein 2
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
Western Blotting
Entrez Gene Summary:
This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
UniProt Summary:
FUNCTION: Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May regulate translation of target mRNAs.
SUBUNIT STRUCTURE: Interacts with HNRPD.
SUBCELLULAR LOCATION: Cytoplasm Probable. Note: Localizes at the connecting piece and the tail of the spermatozoa.
TISSUE SPECIFICITY: Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.
INVOLVEMENT IN DISEASE: Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma.
SEQUENCE SIMLARITIES: Belongs to the RRM IMP/VICKZ family.
Contains 4 KH domains.
Contains 2 RRM (RNA recognition motif) domains.
SUBUNIT STRUCTURE: Interacts with HNRPD.
SUBCELLULAR LOCATION: Cytoplasm Probable. Note: Localizes at the connecting piece and the tail of the spermatozoa.
TISSUE SPECIFICITY: Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.
INVOLVEMENT IN DISEASE: Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma.
SEQUENCE SIMLARITIES: Belongs to the RRM IMP/VICKZ family.
Contains 4 KH domains.
Contains 2 RRM (RNA recognition motif) domains.
Product Name:
Anti-IGF2 mRNA-binding protein 2
Concentration:
1.0 mg/mL
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 μg
Format:
Affinity Purified
Host:
Rabbit