Anti-Histone H4 (citrulline 3)

P62805

FUNCTION: SwissProt: P62805 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
SIZE: 103 amino acids; 11367 Da
SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
SUBCELLULAR LOCATION: Nucleus.
PTM: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). & Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
SIMILARITY: SwissProt: P62805 ## Belongs to the histone H4 family. ... 隠す » もっと見る »

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. ... 隠す » もっと見る »

Anti-Histone H4 (citrulline 3)

histone H4 which has a citrulline at residue 3

• Western Blotting
• Immunohistochemistry

• Human
• Vertebrates

IgG

synthetic peptide corresponding to amino acids 1-10 of human histone H4, where [cit] corresponds to the change of arginine to citrulline at residue 3

10kDa

1 year at -20°C from date of shipment

• HIST1H4A
• H4/J
• HIST1H4F
• HIST1H4L
• H4FN
• H4FA
• H4FH
• HIST1H4H
• H4F2
• H4FM
• H4/A
• H4FK
• H4FG
• HIST2H4
• H4FB
• H4/K
• HIST1H4I
• H4/N
• HIST1H4B
• H4FE
• H4/M
• H4/a
• HIST1H4E
• HIST4H4
• HIST2H4A
• H4FC
• H4FI
• H4/H
• HIST1H4C
• H4/G
• HIST1H4K
• H4FJ
• H4FD
• H4/I
• H4/B
• H4/C
• H4/D
• HIST1H4J
• HIST1H4D
• H4/E

Routinely evaluated by immunoblot with acid extracts from HL-60 differentiated cells treated with calcium ionophore

Epigenetics & Nuclear Function

Histones

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Upstate (Millipore)

Affinity Purified

Rabbit

Polyclonal Antibody

immunoaffinity purified