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ICC: CMXRos (a mitochondrial marker; 1:8,000 dilution; Molecular Probes; red staining) was added to U937 cells growing in suspension, which were then ...
IB: 40 micrograms of rat brain microsomal preparation was probed with anti-Thioredoxin Reductase 1 (1μg/ml)
Anti-Thioredoxin Reductase 1 (TrxR1)
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, R | WB, IC | Rabbit | Affinity Purified | Polyclonal Antibody |
UniProt Number:
UniProt Summary
COFACTOR: Binds 1 FAD per subunit.
SIZE: 499 amino acids; 54707 Da
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
PTM: The N-terminus is blocked. & Contains a selenide-sulfide bond between Cys-497 and Sec-498. This bond is speculated to serve as redox active pair (By similarity).
SIMILARITY: SwissProt: Q16881 ## Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
MISCELLANEOUS: ... see more »
SIZE: 499 amino acids; 54707 Da
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
PTM: The N-terminus is blocked. & Contains a selenide-sulfide bond between Cys-497 and Sec-498. This bond is speculated to serve as redox active pair (By similarity).
SIMILARITY: SwissProt: Q16881 ## Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
MISCELLANEOUS: ... see more »
Entrez Gene Number:
Entrez Gene Summary
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3
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Description:
Anti-Thioredoxin Reductase 1 (TrxR1)
Specificity:
thioredoxin reductase 1
Key Applications:
- Western Blotting
- Immunocytochemistry
Species Reactivity:
- Human
- Rat
Isotype:
IgG
Immunogen:
peptide corresponding to amino acids 137-150 (C-PHRIKATNNKGKEK) of human thioredoxin reductase 1
Molecular Weight:
58kDa
Presentation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Storage Conditions:
1 year at -20°C
Gene Symbol:
- TXNRD1
- TXNR
- oxidoreductase
- TRXR1
- Trxr1
- MGC9145
- TR
- GRIM-12
- TR1
Quality Assurance:
routinely evaluated by immunoblot in RIPA lysates from rat brain microsomal preparation
Antibody Category:
Neuroscience
Antibody Sub-Category:
Oxidative Stress
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Upstate (Millipore)
Format:
Affinity Purified
Host:
Rabbit
Antibody Type:
Polyclonal Antibody
Purification Method:
immunoaffinity purified