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WB: 20 micrograms of 3T3/A31 cell lysate was probed with 0.5μg/ml Anti-phospho-beta 2-Adrenergic Receptor (Thr384).
Anti-phospho-β-2 Adrenergic Receptor (Thr384)
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | WB | Rabbit | Purified | Polyclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: P35626 # Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
SIZE: 688 amino acids; 79710 Da
SIMILARITY: SwissProt: P35626 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 PH domain. & Contains 1 protein kinase domain. & Contains 1 RGS domain.
SIZE: 688 amino acids; 79710 Da
SIMILARITY: SwissProt: P35626 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 PH domain. & Contains 1 protein kinase domain. & Contains 1 RGS domain.
Entrez Gene Number:
Entrez Gene Summary
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
Description:
Anti-phospho-β-2 Adrenergic Receptor (Thr384)
Specificity:
phospho-beta 2-Adrenergic Receptor (Thr384)
Key Applications:
Western Blotting
Species Reactivity:
- Human
- Mouse
- Rat
Isotype:
IgG
Immunogen:
synthetic peptide containing the sequence PGpTED in which pT corresponds to phosphothreonine at residue 384 of human beta 2-Adrenergic Receptor
Modifications:
Phosphorylation
Molecular Weight:
43kDa
Presentation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%.
Storage Conditions:
2 years at -20°C
Gene Symbol:
- ADRBK2
- GRK3
- Beta-ARK-2
- BARK2
Quality Assurance:
routinely evaluated by immunoblot in RIPA lysates from 3T3/A31 cells.
Antibody Category:
Neuroscience
Antibody Sub-Category:
Neurotransmitters & Receptors
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Upstate (Millipore)
Format:
Purified
Host:
Rabbit
Antibody Type:
Polyclonal Antibody
Purification Method:
protein A purified