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WB: 20 micrograms of HeLa nuclear extract was probed with Anti-cdk2 (1μg/ml). Arrow indicates cdk2 (~33kDa).
Anti-cdk2
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | IPK, IP, WB | Rabbit | Purified | Polyclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: P24941 # Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2.
SIZE: 298 amino acids; 33930 Da
SUBUNIT: Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (By similarity). Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC. Found in a complex with both SPDYA an ... see more »
SIZE: 298 amino acids; 33930 Da
SUBUNIT: Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (By similarity). Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC. Found in a complex with both SPDYA an ... see more »
Entrez Gene Number:
Entrez Gene Summary
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A)
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Description:
Anti-cdk2
Specificity:
Recognizes human p33cdk2 protein kinase.
Key Applications:
- IP-Kinase Assay
- Immunoprecipitation
- Western Blotting
Species Reactivity:
Human
Species Reactivity Note:
Predicted to cross-react with mouse, rat, non-human primates, and hamster based on sequence homology
Isotype:
IgG
Immunogen:
peptide corresponding to amino acids 287-298 (C-QDVTKPVPHLRL) of human cdk2
Molecular Weight:
33 kDa
Control:
Colon tissue
Presentation:
Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Gene Symbol:
- CDK2
- p33(CDK2)
Quality Assurance:
routinely evaluated by immunoblot in nuclear extracts from HeLa cells
Antibody Category:
Epigenetics & Nuclear Function
Antibody Sub-Category:
Cell Cycle, DNA Replication & Repair
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Upstate (Millipore)
Format Code:
Pur
Concentration:
1 mg/mL
Antibody Type:
Polyclonal Antibody
Format:
Purified
Host:
Rabbit
Purification Method:
Protein A Purified