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WB: Spinal cord lysate (20μg) from Nova-1 knockout (lane 1) and wild type (lane 2) mice were probed with anti-Nova-1 (1:1000).
Anti-Nova-1
Recommended Replacement for: AB5985| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M, R | WB | Rabbit | Affinity Purified | Polyclonal Antibody |
Description:
Anti-Nova-1
Replaces:
AB5985
Trade Name:
Upstate (Millipore)
Specificity:
Nova-1
Molecular Weight:
53kDa
Immunogen:
synthetic peptide corresponding to amino acids 160-172 of mouse Nova-1
Isotype:
IgG
Species Reactivity:
- Mouse
- Rat
Quality Assurance:
routinely evaluated by immunoblot on mouse spinal cord
Purification Method:
Immunoaffinity purified
Presentation:
0.2M Tris-glycine, pH 7.4, 0.15M NaCl and 0.05% sodium azide before the addition of glycerol to 30%.
Storage Conditions:
1 year at -20°C
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- NOVA1
- Nova-1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.
Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: P51513 # May regulate RNA splicing or metabolism in a specific subset of developing neurons.
SIZE: 510 amino acids; 52056 Da
SUBUNIT: Interacts with PTBP2 (By similarity).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Brain.
DISEASE: SwissProt: P51513 # Autoantigen in the paraneoplastic opsoclonus myoclonus ataxia (POMA), a paraneoplastic neurological syndrome/disorder (PNS/D) associated with breast cancer, fallopian cancer, and SCLCa and characterized primarily by loss of inhibitory control of motor neurons in the spinal cord and brainstem. Recognized by the IgG autoantibody ANNA-2 (also called anti-Ri).
SIMILARITY: SwissProt: P51513 ## Contains 3 KH domains.
SIZE: 510 amino acids; 52056 Da
SUBUNIT: Interacts with PTBP2 (By similarity).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Brain.
DISEASE: SwissProt: P51513 # Autoantigen in the paraneoplastic opsoclonus myoclonus ataxia (POMA), a paraneoplastic neurological syndrome/disorder (PNS/D) associated with breast cancer, fallopian cancer, and SCLCa and characterized primarily by loss of inhibitory control of motor neurons in the spinal cord and brainstem. Recognized by the IgG autoantibody ANNA-2 (also called anti-Ri).
SIMILARITY: SwissProt: P51513 ## Contains 3 KH domains.
Qty/Pk:
100 µL
Brand Family:
Upstate
Format:
Affinity Purified
Host:
Rabbit
Product Name:
Anti-Nova-1
Antibody Type:
Polyclonal Antibody