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Ordering Information
- : 07-650
- : 100 µL
Product Images
IHC: Staining of a 50µm Vibratome section of the hippocampus of an Alzheimer's patient incubated with anti-GFAP+1. (Cat. # 07-650; 1:1,000 ...
WB: Recombinant C-terminal GFAP+1 (~119 amino acids) was resolved by electrophoresis, transferred to nitrocellulose and probed with anti- ...
Anti-GFAP+1
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | WB, IH | Rabbit | Serum | Polyclonal Antibody |
Description:
Anti-GFAP+1
Trade Name:
Upstate (Millipore)
Specificity:
GFAP+1
Molecular Weight:
50kDa
Immunogen:
synthetic peptide corresponding to a neo-C-terminus generated as a result of alternative splicing of the human GFAP mRNA (Hol et al, 2003)
Isotype:
IgG
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot of GFAP+1 protein
Purification Method:
Serum
Presentation:
antiserum containing 0.05% sodium azide and 30% glycerol.
Storage Conditions:
1 year at -20°C
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- GFAP
- FLJ45472
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant has been described, but its full length sequence has not been determined.
Key Applications:
- Western Blotting
- Immunohistochemistry
UniProt Summary:
FUNCTION: SwissProt: P14136 # GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
SIZE: 432 amino acids; 49880 Da
SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1.
SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.
DISEASE: SwissProt: P14136 # Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
SIMILARITY: SwissProt: P14136 ## Belongs to the intermediate filament family.
SIZE: 432 amino acids; 49880 Da
SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1.
SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.
DISEASE: SwissProt: P14136 # Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
SIMILARITY: SwissProt: P14136 ## Belongs to the intermediate filament family.
Qty/Pk:
100 µL
Brand Family:
Upstate
Format:
Serum
Host:
Rabbit
Product Name:
Anti-GFAP+1
Antibody Type:
Polyclonal Antibody