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IB: HeLa acid extract (Lane 1) and unmethylated recombinant Histone H4 (Catalog # 14-412) (Lane 2), were probed with anti-dimethyl-Histone H4 (Lys20) ...
Anti-dimethyl-Histone H4 (Lys20)
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | WB | Rabbit | Purified | Polyclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: P62805 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
SIZE: 103 ami ... see more »
SIZE: 103 ami ... see more »
Entrez Gene Number:
Entrez Gene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of
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Description:
Anti-dimethyl-Histone H4 (Lys20)
Trade Name:
Upstate (Millipore)
Key Applications:
Western Blotting
Species Reactivity:
Human
Species Reactivity Note:
Broad species cross-reactivity is expected
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular Weight:
10kDa
Presentation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide and 30% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment
Isotype:
IgG
Modifications:
Methylation
Gene Symbol:
- HIST2H4B
- H4/J
- HIST1H4F
- HIST1H4L
- H4FN
- H4FA
- H4FH
- HIST1H4H
- H4F2
- H4FM
- H4/A
- H4FK
- H4FG
- H4/o
- HIST2H4
- H4FB
- H4/K
- HIST1H4I
- H4/N
- HIST1H4B
- H4FE
- H4/M
- HIST1H4E
- HIST4H4
- HIST2H4A
- H4FC
- H4FI
- H4/H
- HIST1H4C
- H4/G
- HIST1H4K
- H4FJ
- H4FD
- H4/I
- H4/B
- H4/C
- H4/D
- HIST1H4J
- HIST1H4D
- H4/E
Antibody Type:
Polyclonal Antibody
Specificity:
dimethylated Histone H4 (Lys20)
Quality Assurance:
Routinely evaluated by immunoblot
Immunogen:
KLH-conjugated, branched synthetic peptide corresponding to amino acids 15-25 (AKRHR[me2K]VLRDN) of histone H4
Format:
Purified
Host:
Rabbit
Antibody Category:
Epigenetics & Nuclear Function
Antibody Sub-Category:
Histones
Purification Method:
protein A purified