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Ordering Information
- : 07-914
- : 100 µg
- : 0.5 mg/mL
Product Images
Western Blot: 20 μg of the following Lysates are loaded as follows: Lane 1 is HeLa cell lysate, Lane 2 is 293 cell lysate, Lane 3 is A431 cell lysate,...
Anti-STAT6
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | WB | Rabbit | Affinity Purified | Polyclonal Antibody |
Description:
Anti-STAT6
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes STAT6.
Molecular Weight:
94kDa
Immunogen:
Synthetic peptide encompassing the C-terminal region of human STAT6.
Isotype:
IgG
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Affinity Purfied
Presentation:
Affinity purified Rabbit polyclonal IgG in phosphate buffer, pH 7.4. Carrier and preservative free.
Storage Conditions:
2 years at -80°C from date of shipment
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -80°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -80°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- STAT6
- STAT6C
- D12S1644
- STAT6B
- IL-4-STAT
Alternate Names:
Signal transducer and activator of transcription 6; IL-4 Stat
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: P42226 # Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
SIZE: 847 amino acids; 94135 Da
SUBUNIT: Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
PTM: Tyrosine phosphorylated following stimulation by IL-4 and IL- 3 (By similarity).
SIMILARITY: SwissProt: P42226 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
SIZE: 847 amino acids; 94135 Da
SUBUNIT: Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
PTM: Tyrosine phosphorylated following stimulation by IL-4 and IL- 3 (By similarity).
SIMILARITY: SwissProt: P42226 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
Qty/Pk:
100 µg
Brand Family:
Upstate
Format:
Affinity Purified
Host:
Rabbit
Product Name:
Anti-STAT6
Concentration:
0.5 mg/mL
Antibody Type:
Polyclonal Antibody