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Western Blot (SNAP ID) Analysis from Reprentative Lot:
Human brain lysate was resolved by electrophoresis, transferred to PVDF membranes and pro...
Western Blot Analysis from Representative Lot:
10 mg of Human brain lysate was resolved by electrophoresis, transferred to PVDF membranes and pr...
Anti-HDAC11 Antibody
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | WB | Rabbit | Affinity Purified | Polyclonal Antibody |
Description:
Anti-HDAC11 Antibody | 09-827
Promotional Text:
Specificity:
This antibody recognizes HDAC11.
Molecular Weight:
39 kDa
Epitope:
Amino Acid: 228-246
Immunogen:
Linear Peptide corresponding to human HDAC11 at amino acids 228-246.
Background Information:
HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation is a marker for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
Species Reactivity:
- Human
- Mouse
- Rat
Species Reactivity Note:
Demonstrated to react with human, mouse, and rat.
Application Notes:
Western Blot (SNAP ID) Analysis: 0.5 µg/ml from a representative lot detected HDAC11 on 10 µg of human brain tissue lysate.
Control:
Human brain tissue lysate
Quality Assurance:
Evaluated by Western Blot in human brain tissue lysate.
Western Blot Analysis: 0.05 µg/ml of this antibody detected HDAC11 on 10 µg of human brain tissue lysate.
Western Blot Analysis: 0.05 µg/ml of this antibody detected HDAC11 on 10 µg of human brain tissue lysate.
Purification Method:
Affinity Purfied
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- HDAC11
- HD11
Alternate Names:
histone deacetylase 11
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
Western Blotting
Entrez Gene Summary:
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.
UniProt Summary:
FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
SUBUNIT STRUCTURE: Interacts with HDAC6.
SUBCELLULAR LOCATION: Nucleus. Note: Predominantly nuclear.
TISSUE SPECIFICTY: Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.
MISCELLANEOUS: Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
SEQUENCE SIMILARITIES: Belongs to the histone deacetylase family.
SEQUENCE CAUTION: The sequence BAB15127.1 differs from that shown. Reason: Erroneous termination at position 107. Translated as Gln.
The sequence CAB70712.1 differs from that shown. Reason: Frameshift at positions 177, 198 and 200.
CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
SUBUNIT STRUCTURE: Interacts with HDAC6.
SUBCELLULAR LOCATION: Nucleus. Note: Predominantly nuclear.
TISSUE SPECIFICTY: Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.
MISCELLANEOUS: Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
SEQUENCE SIMILARITIES: Belongs to the histone deacetylase family.
SEQUENCE CAUTION: The sequence BAB15127.1 differs from that shown. Reason: Erroneous termination at position 107. Translated as Gln.
The sequence CAB70712.1 differs from that shown. Reason: Frameshift at positions 177, 198 and 200.
Product Name:
Anti-HDAC11 Antibody (09-827)
Concentration:
1 mg/mL
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 μg
Format:
Affinity Purified
Host:
Rabbit