ACC2 (aa 175-271)

ACC2 (aa 175-271)

Upstate (Millipore)

1 mg

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Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms.

FUNCTION: SwissProt: O00763 # ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
COFACTOR: Biotin (By similarity). & Binds 2 manganese ions per subunit (By similarity).
SIZE: 2458 amino acids; 276555 Da
SUBCELLULAR LOCATION: Intracytoplasmic membrane. Note=May associate with membranes.
TISSUE SPECIFICITY: Predominantly expressed in the heart, skeletal muscles and liver.
SIMILARITY: SwissProt: O00763 ## Contains 1 ATP-grasp domain. & Contains 1 biotin carboxylation domain. & Contains 1 biotinyl-binding domain. & Contains 1 carboxyltransferase domain.

Human

Routinely evaluated for use as a substrate in a kinase assay.

Upstate

50mM Tris-HCl, pH 8.0, 150mM NaCl, and 20mM glutathione, before the addition of glycerol to 20%

O00763

1 year at -20°C

• ACACB
• ACC2
• ACCB
• ACC-beta
• HACC275

• Kinases
• Control Proteins & Peptides
• Substrate Proteins & Peptides
• Peptides

ACC2 (aa 175-271)

NM_001093.3