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Ordering Information
- : 14-155
- : 20 mg
Histone H1
Description:
Histone H1
Trade Name:
Upstate (Millipore)
Qty/Pk:
20 mg
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
UniProt Summary:
FUNCTION: SwissProt: P10412 # Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.
SIZE: 219 amino acids; 21865 Da
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: SwissProt: P10412 ## Belongs to the histone H1/H5 family.
MISCELLANEOUS: This variant accounts for 60% of histone H1.
SIZE: 219 amino acids; 21865 Da
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: SwissProt: P10412 ## Belongs to the histone H1/H5 family.
MISCELLANEOUS: This variant accounts for 60% of histone H1.
Species:
Bovine
Molecular Weight:
32kDa
Quality Assurance:
Routinely evaluated by Kinase assay using cdk2/cyclin A, active (14-448) to phosphorylate Histone H1.
Brand Family:
Upstate
Sales Restrictions:
This product is derived from bovine source. Export of this product to certain countries may be restricted. Please contact Customer Service or your local distributor to inquire about product availability and export options.
Source:
Lysine rich fraction from calf thymus
UniProt Number:
Storage Conditions:
1 year at -20°C
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Gene Symbol:
- HIST1H1E
- dJ221C16.5
- H1.4
- H1F4
- MGC116819
Protein or Enzyme Type:
- Histones and Histone-Modifying Enzymes
- Kinases
Product Name:
Histone H1
Entrez Gene Number:
Purification Method:
Sterilized through a 0.2 micron membrane filter