Brasil
Calmodulin
Description:
Calmodulin
Trade Name:
Upstate (Millipore)
Qty/Pk:
100 µg
Product Overview:
Recombinant bovine calmodulin
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
Calmodulin is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 149 amino acids and has 4 calcium-binding domains. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters.[supplied by OMIM]
UniProt Summary:
FUNCTION: SwissProt: P62158 # Calmodulin mediates the control of a large number of enzymes and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
SIZE: 149 amino acids; 16838 Da
SUBUNIT: Interacts with TTN/titin and SRY.
PTM: Ubiquitination results in a strongly decreased activity (By similarity). & Phosphorylation results in a decreased activity (By similarity).
SIMILARITY: SwissProt: P62158 ## Belongs to the calmodulin family. & Contains 4 EF-hand domains.
MISCELLANEOUS: This protein has four functional calcium-binding sites.
SIZE: 149 amino acids; 16838 Da
SUBUNIT: Interacts with TTN/titin and SRY.
PTM: Ubiquitination results in a strongly decreased activity (By similarity). & Phosphorylation results in a decreased activity (By similarity).
SIMILARITY: SwissProt: P62158 ## Belongs to the calmodulin family. & Contains 4 EF-hand domains.
MISCELLANEOUS: This protein has four functional calcium-binding sites.
Species:
Bovine
Molecular Weight:
16kDa
Brand Family:
Upstate
Source:
expressed in E. coli.
Protein Target:
Calmodulin
UniProt Number:
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Storage Conditions:
stable at -20°C from date of shipment
Protein/Isoform Description:
Calmodulin is the principal intracellular calcium receptor. It is an acidic protein of 148 residues, and upon binding Ca2+, it in turn binds to short peptide sequences of many target proteins. Such interaction is thought to induce a conformational change on the target, resulting in its activation. Targets include the constitutively expressed nitric oxide synthases, the CaM kinases, and PP2B/Calcineurin.
Gene Symbol:
- CALM1
- CALML2
- PHKD
- CAMI
- Calmodulin
- CALM3
- CALM
- CaM
- CALM2
- CAM2
- CAMB
- CAMC
- CAM3
- CAM
- DD132
- CAM1
- CAMIII
Protein or Enzyme Type:
- Kinases
- Recombinant Protein
Product Name:
Calmodulin
Entrez Gene Number:
Purification Method:
Purified with phenyl Sepharose™ with and without calcium