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Casein Kinase 2α, active
Description:
Casein Kinase 2α, active
Trade Name:
Upstate (Millipore)
Qty/Pk:
10 µg
Product Overview:
6His-tagged recombinant fulllength Casein Kinase 2α, human
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.
UniProt Summary:
FUNCTION: SwissProt: P67870 # Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
SIZE: 215 amino acids; 24942 Da
SUBUNIT: Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation.
PTM: Phosphorylated by alpha subunit.
SIMILARITY: SwissProt: P67870 ## Belongs to the casein kinase 2 subunit beta family.
SIZE: 215 amino acids; 24942 Da
SUBUNIT: Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation.
PTM: Phosphorylated by alpha subunit.
SIMILARITY: SwissProt: P67870 ## Belongs to the casein kinase 2 subunit beta family.
Species:
Human
Molecular Weight:
48.7kDa
Quality Assurance:
Casein Kinase 2 Substrate Peptide
Brand Family:
Upstate
Source:
Expressed in Sf21
Protein Target:
CK2α
UniProt Number:
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Storage Conditions:
1 year at -20°C
Target Sub-Family:
CMGC
Packaging:
Also available in 250μg size as catalog # 14-445M - Call for pricing and availability.
Gene Symbol:
- CSNK2B
- Phosvitin
- CK2B
- CSK2B
- MGC138224
- MGC138222
- CK2N
- G5a
- phosvitin
- G5A
Protein or Enzyme Type:
- Kinases
- Signal Transduction
Product Name:
Casein Kinase 2α, active
Purification Method:
Ni2+/NTA-agarose