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Cdk3/Cyclin E, active
Description:
Cdk3/Cyclin E, active
Trade Name:
Upstate (Millipore)
Qty/Pk:
10 µg
Product Overview:
Complex of recombinant full length human cdk3 containing a C-terminal His6-tag, and recombinant full-length human cyclin E containing an N-terminal GST-tag
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.
UniProt Summary:
FUNCTION: SwissProt: Q00526 # Probably involved in the control of the cell cycle. Interacts with a yet unknown type of cyclin. Can phosphorylate histone H1.
SIZE: 305 amino acids; 35046 Da
SUBUNIT: Interacts with CABLES1 (By similarity).
SIMILARITY: SwissProt: Q00526 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
SIZE: 305 amino acids; 35046 Da
SUBUNIT: Interacts with CABLES1 (By similarity).
SIMILARITY: SwissProt: Q00526 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
Species:
Human
Molecular Weight:
36kDa (cdk3), 74kDa (cyclin E)
Quality Assurance:
routinely evaluated by phosphorylation of Histone H1
Brand Family:
Upstate
Source:
Both are expressed by baculovirus in Sf21 insect cells
Protein Target:
CDK3/cyclinE
UniProt Number:
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Storage Conditions:
1 year at -70°C
Target Sub-Family:
CMGC
Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
Packaging:
Also available in 250μg size as catalog # 14-487M - Call for pricing and availability.
Gene Symbol:
CDK3
Protein or Enzyme Type:
- Kinases
- Signal Transduction
Product Name:
Cdk3/Cyclin E, active
Entrez Gene Number:
Purification Method:
Ni-NTA agarose