Ordering Information
- : 14-499
- : 10 µg
Bmx Protein, active, 10 μg
Description:
Bmx, active
Trade Name:
Upstate (Millipore)
Qty/Pk:
10 µg
Product Overview:
N-terminal His6 tagged, recombinant, full length, human Bmx
Applications:
10 µg of Bmx. Active, N-terminal His6 tagged, recombinant, full length, human Bmx, for use in Kinase Assays.
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
Tyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC (MIM 600583), TXK (MIM 600058), ITK (MIM 186973), and BTK (MIM 300300). All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain.[supplied by OMIM]
UniProt Summary:
FUNCTION: SwissProt: P51813 # Activity is required for interleukin 6 (IL-6) induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells.
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
SIZE: 675 amino acids; 78011 Da
SUBUNIT: Interacts with RUFY1 and RUFY2.
SUBCELLULAR LOCATION: Cytoplasm (Probable).
TISSUE SPECIFICITY: Preferentially expressed in epithelial and endothelial cells.
DOMAIN: SwissProt: P51813 SH2 domain mediates interaction with RUFY1.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. & Contains 1 Btk-type zinc finger. & Contains 1 PH domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain.
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
SIZE: 675 amino acids; 78011 Da
SUBUNIT: Interacts with RUFY1 and RUFY2.
SUBCELLULAR LOCATION: Cytoplasm (Probable).
TISSUE SPECIFICITY: Preferentially expressed in epithelial and endothelial cells.
DOMAIN: SwissProt: P51813 SH2 domain mediates interaction with RUFY1.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. & Contains 1 Btk-type zinc finger. & Contains 1 PH domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain.
Species:
Human
Molecular Weight:
79kDa
Brand Family:
Upstate
Source:
expressed in Sf21 cells
Protein Target:
Bmx
Storage Conditions:
6 months at -70C
Target Sub-Family:
TK
Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
Gene Symbol:
- BMX
- PSCTK2
- PSCTK3
- NTK38
- ETK
Product Name:
Bmx, active
Quality Assurance:
routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
UniProt Number:
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Packaging:
Also available in 250μg size as catalog # 14-499M - Call for pricing and availability.
Entrez Gene Number:
Purification Method:
Ni2+/NTA-agarose