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Cdk6/Cyclin D3, active
Description:
Cdk6/Cyclin D3, active
Trade Name:
Upstate (Millipore)
Qty/Pk:
10 µg
Product Overview:
N-terminal, His6-tagged fulllength human cdk6 complexed with N-terminal GSTtagged full-length human cyclin D3
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.
UniProt Summary:
FUNCTION: SwissProt: Q00534 # Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins.
SIZE: 326 amino acids; 36938 Da
SIMILARITY: SwissProt: Q00534 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
SIZE: 326 amino acids; 36938 Da
SIMILARITY: SwissProt: Q00534 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
Species:
Human
Molecular Weight:
38kDa (cdk6) and 59kDa (cyclin D3)
Quality Assurance:
routinely evaluated by phosphorylation of histone H1
Brand Family:
Upstate
Source:
expressed in Sf21 cells
Protein Target:
CDK6/cyclinD3
UniProt Number:
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Target Sub-Family:
CMGC
Storage Conditions:
6 months at -70°C
Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
Packaging:
Also available in 250μg size as catalog # 14-519M - Call for pricing and availability.
Gene Symbol:
- CDK6
- PLSTIRE
- MGC59692
Protein or Enzyme Type:
- Kinases
- Signal Transduction
Product Name:
Cdk6/Cyclin D3, active
Entrez Gene Number:
Purification Method:
Glutathione-agarose