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CaM Kinase IV, active
Description:
CaM Kinase IV, active
Trade Name:
Upstate (Millipore)
Qty/Pk:
10 µg
Product Overview:
C-terminal His6-tagged, recombinant, full-length, human CaM Kinase IV
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.
UniProt Summary:
FUNCTION: SwissProt: Q16566 # Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory (By similarity).
SIZE: 473 amino acids; 51926 Da
SUBUNIT: Monomer (By similarity). Interacts with serine/threonine protein phosphatase 2A catalytic subunit, PPP2CA or PPP2CB. The interaction with PP2CA or PP2CB is mutually exclusive with binding to Ca(2+)/calmodulin.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix (By similarity).
TISSUE SPECIFICITY: Expressed in epithelial ovarian cancer tissue.
PTM: Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity). Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200.
SIMILARITY: SwissProt: Q16566 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain.
SIZE: 473 amino acids; 51926 Da
SUBUNIT: Monomer (By similarity). Interacts with serine/threonine protein phosphatase 2A catalytic subunit, PPP2CA or PPP2CB. The interaction with PP2CA or PP2CB is mutually exclusive with binding to Ca(2+)/calmodulin.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix (By similarity).
TISSUE SPECIFICITY: Expressed in epithelial ovarian cancer tissue.
PTM: Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity). Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200.
SIMILARITY: SwissProt: Q16566 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain.
Species:
Human
Molecular Weight:
52.9kDa
Quality Assurance:
routinely evaluated by phosphorylation of MAPKAP Kinase 2 Substrate Peptide
Brand Family:
Upstate
Source:
expressed by baculovirus in Sf21 insect cells
Protein Target:
CaMKIV
UniProt Number:
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Target Sub-Family:
CAMK
Storage Conditions:
6 months at -70°C
Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
Packaging:
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-547M when ordering the 250 µg size.
Gene Symbol:
- CAMK4
- MGC36771
- CaMK-GR
Protein or Enzyme Type:
- Kinases
- Signal Transduction
Product Name:
CaM Kinase IV, active
Entrez Gene Number:
Purification Method:
Ni2+/NTA-agarose