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Sample enzyme activity data. See certificate of analysis for lot specific activity data.
PI3 Kinase (p120γ)
Description:
PI3 Kinase (p120γ)
Trade Name:
Upstate (Millipore)
Qty/Pk:
20 µg
Product Overview:
N-terminal His6-tagged recombinant full-length human PI 3-kinase (p120γ).
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
UniProt Summary:
FUNCTION: SwissProt: P48736 # 3-phosphorylates the cellular phosphoinositide PtdIns- 4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5- triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.
SIZE: 1102 amino acids; 126454 Da
SUBUNIT: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit.
TISSUE SPECIFICITY: Pancreas, skeletal muscle, liver and heart.
SIMILARITY: SwissProt: P48736 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
SIZE: 1102 amino acids; 126454 Da
SUBUNIT: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit.
TISSUE SPECIFICITY: Pancreas, skeletal muscle, liver and heart.
SIMILARITY: SwissProt: P48736 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
Species:
Human
Molecular Weight:
130kDa
Brand Family:
Upstate
Source:
Expressed by baculovirus in Sf21 insect cells
Protein Target:
PI3Kγ
Storage Conditions:
6 months at -70°C
Target Sub-Family:
PI3K/PI4K
Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
Gene Symbol:
- PIK3CG
- p110-gamma
- PI3-kinase
- PIK3
- PI3K
- PI3Kgamma
- PTDINS-3-kinase
- PI3CG
- p120-PI3K
Protein or Enzyme Type:
- Kinases
- Signal Transduction
Product Name:
PI3 Kinase (p120γ)
Quality Assurance:
Routinely evaluated in the PIProfiler.
UniProt Number:
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Packaging:
Also available in 250μg size as catalog # 14-558M - Call for pricing and availability.
Entrez Gene Number:
Purification Method:
Ni2+/NTA-agarose