Ordering Information
- : 14-604
- : 10 µg
PI3 Kinase (p110δ/p85α) Protein, active, 10 μg
Description:
PI3 Kinase (p110δ/p85α), active
Trade Name:
Upstate (Millipore)
Qty/Pk:
10 µg
Product Overview:
Complex of N-terminal His6-tagged recombinant, full-length, human p110δ and untagged, recombinant, full length, human p85α
Applications:
10 µg of PI3 Kinase (p110δ/p85α). Active complex of N-terminal His6-tagged recombinant, full-length, human p110δ and untagged, recombinant, full length, human p85α. For use in Kinase Assays.
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. See MIM 602838. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha (MIM 171834), p110-beta (MIM 602925), and p110-gamma (MIM 601232). p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins (see MIM 171833) and with GTP-bound Ras.[supplied by OMIM]
UniProt Summary:
SIZE: 1044 amino acids; 119479 Da
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Interacts with ERAS (By similarity).
TISSUE SPECIFICITY: Expressed predominantly in leukocytes.
PTM: Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity.
SIMILARITY: SwissProt: O00329 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Interacts with ERAS (By similarity).
TISSUE SPECIFICITY: Expressed predominantly in leukocytes.
PTM: Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity.
SIMILARITY: SwissProt: O00329 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
Species:
Human
Molecular Weight:
P110δ (121.6kDa) & p85α (83.7kDa)
Brand Family:
Upstate
Source:
Coexpressed by baculovirus in Sf21 insect cells
Protein Target:
PI3Kδ/p85α
Storage Conditions:
6 months at -70°C
Target Sub-Family:
PI3K/PI4K
Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
Gene Symbol:
- PIK3CD
- p110d
- PI3K
- p110D
- p110delta
Product Name:
PI3 Kinase (p110δ/p85α), active
Quality Assurance:
routinely evaluated by the PIProfiler™
UniProt Number:
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Packaging:
Also available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-604M when ordering the 250μg size.
Entrez Gene Number:
Purification Method:
Ni2+/NTA-agarose