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EphA5, active
Description:
EphA5, active
Trade Name:
Upstate (Millipore)
Qty/Pk:
10 µg
Product Overview:
N-terminal His6-tagged human EphA5, expressed by baculovirus in Sf21 cells
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
UniProt Summary:
FUNCTION: SwissProt: P54756 # Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A2, -A3, -A4 and -A5.
SIZE: 1037 amino acids; 114784 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Almost exclusively expressed in the nervous system.
SIMILARITY: SwissProt: P54756 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
SIZE: 1037 amino acids; 114784 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Almost exclusively expressed in the nervous system.
SIMILARITY: SwissProt: P54756 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
Species:
Human
Molecular Weight:
37.9kDa
Quality Assurance:
routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) substrate
Brand Family:
Upstate
Source:
recombinant human EphA5, amino acids 655-956
Protein Target:
EphA5
UniProt Number:
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Storage Conditions:
6 months at -70°C
Target Sub-Family:
TK
Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
Gene Symbol:
- EPHA5
- EphA5
- EHK1
- TYRO4
- HEK7
- CEK7
- Hek7
Protein or Enzyme Type:
Kinases
Product Name:
EphA5, active
Entrez Gene Number:
Purification Method:
Ni2+/NTA-agarose