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CaM Kinase IIγ, active
Description:
CaM Kinase IIγ, active
Trade Name:
Upstate (Millipore)
Qty/Pk:
10 µg
Product Overview:
N-terminal 6His-tagged, recombinant, CaM Kinase IIγ, amino acids 1-330
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined.
UniProt Summary:
FUNCTION: SwissProt: Q13555 # CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.
SIZE: 558 amino acids; 62609 Da
SUBUNIT: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.
SIMILARITY: SwissProt: Q13555 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain.
SIZE: 558 amino acids; 62609 Da
SUBUNIT: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.
SIMILARITY: SwissProt: Q13555 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain.
Species:
Human
Molecular Weight:
41.2kDa
Quality Assurance:
routinely evaluated by phosphorylation of 250μM ZIPtide (Catalog # 12-545)
Brand Family:
Upstate
Source:
expressed by baculovirus in Sf21 cells
Protein Target:
CaMKIIγ
UniProt Number:
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Storage Conditions:
6 months at -70°C from date of shipment
Target Sub-Family:
CAMK
Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
Gene Symbol:
- CAMK2G
- MGC26678
- CAMKG
- CAMK-II
- CAMK
- FLJ16043
Protein or Enzyme Type:
Kinases
Product Name:
CaM Kinase IIγ, active
Entrez Gene Number:
Purification Method:
Ni2+/NTA-agarose