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CLK3, active
Description:
CLK3, active
Trade Name:
Upstate (Millipore)
Qty/Pk:
10 µg
Product Overview:
N-terminal 6His-tagged, recombinant full length human CLK3
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. Pseudogenes located on chromosomes 1 and 9 have been found for this gene.
UniProt Summary:
FUNCTION: SwissProt: P49761 # Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines.
SIZE: 638 amino acids; 73515 Da
SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity). Acrosome (By similarity).
PTM: Autophosphorylates on all three types of residues (By similarity).
SIMILARITY: SwissProt: P49761 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. & Contains 1 protein kinase domain.
SIZE: 638 amino acids; 73515 Da
SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity). Acrosome (By similarity).
PTM: Autophosphorylates on all three types of residues (By similarity).
SIMILARITY: SwissProt: P49761 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. & Contains 1 protein kinase domain.
Species:
Human
Molecular Weight:
63kDa
Quality Assurance:
routinely evaluated by phosphorylation of 500μM PKC Substrate Peptide 2 (Catalog # 12-411)
Brand Family:
Upstate
Source:
expressed by baculovirus in Sf21 cells
Protein Target:
CLK3
UniProt Number:
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Storage Conditions:
6 months at -70°C from date of shipment
Target Sub-Family:
CMGC
Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
Gene Symbol:
- CLK3
- FLJ22858
- clk3
Protein or Enzyme Type:
Kinases
Product Name:
CLK3, active
Entrez Gene Number:
Purification Method:
Ni2+/NTA-agarose