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Sample enzyme activity data. See certificate of analysis for lot specific activity data.
PI3 Kinase (p110α (H1047R)/p85α) Murine
Description:
PI3 Kinase (p110α (H1047R)/p85α) Murine
Product Overview:
Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R αand untagged, recombinant, full length mouse p85α.
Background Information:
The H1047R substitution in p110α is associated with a number of human cancers. The residue is conserved between the human and mouse sequences. In vitro studies have shown that this mutation confers increased lipid kinase activity compared to wild type, and is able to induce oncogenic transformation.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Packaging:
Also available in 250µg size --call for pricing and availability and reference catalog number 14-787M when ordering the 250µg size.
Purification Method:
Ni2+/NTA agarose
Gene Symbol:
- PIK3CA
- PI3K
- MGC142161
- p110-alpha
- MGC142163
Protein Type:
Kinase
Molecular Weight:
p110α (H1047R) MW = 129kDa, p85α MW = 83.6kDa
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Storage Conditions:
Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
Source:
Coexpressed by baculovirus in Sf21 insect cells.