Ordering Information
- : 14-788
- : 10 μg
Product Images
Sample enzyme activity data. See certificate of analysis for lot specific activity data.
PI3 Kinase (p110β/p85β) Murine, 10 μg
Description:
PI3 Kinase (p110β/p85β) Murine
Trade Name:
Upstate (Millipore)
Qty/Pk:
10 μg
Product Overview:
Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110β and untagged, recombinant, full length mouse p85β.
Applications:
10 μg of PI3 Kinase (p110β/p85β) Murine. Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110β and untagged, recombinant, full length mouse p85β. For use in Kinase Assays.
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993 [PubMed 8246984]).[supplied by OMIM]
UniProt Summary:
FUNCTION: SwissProt: P42338 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
SIZE: 1070 amino acids; 122762 Da
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit.
TISSUE SPECIFICITY: Expressed ubiquitously.
SIMILARITY: SwissProt: P42338 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
SIZE: 1070 amino acids; 122762 Da
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit.
TISSUE SPECIFICITY: Expressed ubiquitously.
SIMILARITY: SwissProt: P42338 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
Species:
Mouse
Molecular Weight:
p110β MW = 125.5kDa, p85β MW = 81.4kDa
Brand Family:
Upstate
Source:
Coexpressed by baculovirus in Sf21 insect cells.
Protein Target:
PI3Kβ/p85β
Storage Conditions:
Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
Target Sub-Family:
PI3K/PI4K
Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
Gene Symbol:
- PIK3CB
- DKFZp779K1237
- PI3K
- p110-BETA
- PI3Kbeta
- MGC133043
- PIK3C1
Product Name:
PI3 Kinase (p110β/p85β) Murine
UniProt Number:
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Packaging:
Also available in 250μg size --call for pricing and availability and reference catalog number 14-788M when ordering the 250μg size.
Entrez Gene Number:
Purification Method:
Ni2+/NTA-agarose