Ordering Information
- : 14-924
- : 10 µg
TYK2 Protein, active, 10 μg
Description:
TYK2, active
Qty/Pk:
10 µg
Product Overview:
TYK2 is member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Applications:
10 µg of TYK2. Active, TN-terminal 6His-tagged, recombinant, human TYK2, amino acids 875-end. For use in Kinase Assays.
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Species:
Human
Molecular Weight:
40 kDa
Brand Family:
Upstate
Source:
N-terminal 6His-tagged, recombinant, human TYK2 amino acids 875-end, expressed by baculovirus in Sf21 insect cells.
Protein Target:
TYK2
Presentation:
50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol
Storage Conditions:
6 months at -70°C
Target Sub-Family:
TK
Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
Gene Symbol:
- TYK2
- JTK1
Product Name:
TYK2, active
Quality Assurance:
Routinely evaluated by phosphorylation of peptide GGMEDIYFEFMGGKKK
UniProt Number:
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Packaging:
Also available in 250μg size as catalog # 14-924M and in bulk as catalog # 14-924-K.
Entrez Gene Number:
Purification Method:
Purified using immobilized metal affinity chromatography followed by gel filtration.