Ordering Information
- : 14-926
- : 10 µg
IKKε, active
Description:
IKKε, active
Qty/Pk:
10 µg
Product Overview:
IKBKE is a noncanonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Species:
Human
Molecular Weight:
109 kDa
Quality Assurance:
Routinely evaluated by phosphorylation of casein.
Brand Family:
Upstate
Source:
N-terminal FLAG and GST-tagged, recombinant, human IKK full length, expressed by baculovirus in Sf21 insect cells.
Presentation:
50mM Tris/HCl pH7.5, 150mM NaCl, 10mM β-glycerophosphate, 1mM sodium orthovanadate, 1mM NaF, 28% v/v glycerol, 0.03% Brij-35, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol
Protein Target:
IKKe
UniProt Number:
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Target Sub-Family:
Misc
Storage Conditions:
6 months at -70°C
Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
Packaging:
Also available in 250μg size as catalog # 14-926M and in bulk as catalog # 14-926-K.
Gene Symbol:
- IKBKE
- IKKe
- IKKI
- KIAA0151
Product Name:
IKKε, active
Entrez Gene Number:
Purification Method:
Purified by immunoaffinity chromatography.