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Ordering Information
- : 16-241
- : 100 µg
Product Images
Immunoblot Analysis:
2μg of this lot detected CD3ε in Jurkat cell lysate.
Anti-CD3ε, clone APA1/1, Alexa Fluor® 488 conjugate
Recommended Replacement for: CBL1317F| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M | FC, WB | Mouse | Purified | Monoclonal Antibody |
Description:
Anti-CD3ε, clone APA1/1, Alexa Fluor® 488 conjugate
Replaces:
CBL1317F
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes CD3ε. Clone APA1/1 has been demonstrated to recognize a site on CD3ε that is exposed upon engagement of the T-cell Receptor complex
Molecular Weight:
23kDa
Immunogen:
Purified human CD3ε.
Isotype:
IgG1
Species Reactivity:
- Human
- Mouse
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Protein G purfied
Storage Conditions:
1 year at 2-8°C from date of shipment
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- CD3E
- T3E
- TCRE
Usage Statement:
- Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
- Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Key Applications:
- Flow Cytometry
- Western Blotting
UniProt Summary:
FUNCTION: SwissProt: P07766 # The CD3 complex mediates signal transduction.
SIZE: 207 amino acids; 23147 Da
SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P07766 ## Contains 1 Ig-like (immunoglobulin-like) domain. & Contains 1 ITAM domain.
SIZE: 207 amino acids; 23147 Da
SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P07766 ## Contains 1 Ig-like (immunoglobulin-like) domain. & Contains 1 ITAM domain.
Qty/Pk:
100 µg
Brand Family:
Upstate
Format:
Purified
Host:
Mouse
Product Name:
Anti-CD3ε, clone APA1/1, Alexa Fluor® 488 conjugate
Antibody Type:
Monoclonal Antibody