Ordering Information
- : 171260-5MG
- : 5 MG
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AMPK Inhibitor, Compound C | CAS 866405-64-3 | Calbiochem | 5MG
Description:
AMPK Inhibitor, Compound C | CAS 866405-64-3 | Calbiochem | 5MG
Trade Name:
Calbiochem (EMD Millipore)
Qty/Pk:
5 MG
Background Information:
A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 μM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 μM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No.317240)) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Also available as a 10 mM solution in DMSO (Cat. No.171261).
Applications:
The AMPK Inhibitor, Compound C, also referenced under CAS 866405-64-3, controls the biological activity of AMPK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular Weight:
399.5
CAS No.:
866405-64-3
Brand Family:
Calbiochem
Presentation:
Light yellow solid. Packaged under inert gas.
UniProt Number:
Storage Conditions:
Shipped Ambient Temperature, or on Blue Ice or Dry Ice. Store at +2 - 8°C.
Properties:
Solubility: DMSO (4 mg/ml), 2% HCl (10 mg/ml), 2% Acetic Acid (10 mg/ml), or Methanol (3 mg/ml).
Gene Symbol:
PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2
PubChem ID:
26758223
Product Name:
AMPK Inhibitor, Compound C | CAS 866405-64-3 | Calbiochem | 5MG
Entrez Gene Number:
Empirical Formula:
C24H25N5O
Alternate Names:
- 6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine
- Dorsomorphin
- BMP Inhibitor I
Purity:
≥95% by HPLC